This paper presents research conducted with a unique college level course called “The Art and Math of Origami”. As the title suggests, this course teaches about the art of paper folding while integrating mathematical concepts. Data collected over a seven year period is presented illustrating the impact Origami can have on spatial ability, a mathematical skill linked to geometry and with ties to careers such as architecture and engineering. The most current year's research also shows potential benefits related to students behaviors including creativity and attitude. Results, as a whole, are promising illustrating that Origami itself has an inherent connection to mathematics and can benefit those that practice it.